[Acute traumatic spinal cord injuries: Epidemiology and prospects]

Neurochirurgie. 2012 Oct;58(5):293-9. doi: 10.1016/j.neuchi.2012.06.003. Epub 2012 Sep 7.
[Article in French]


Objective: Specify the epidemiological data on the acute spinal cord injuries and define a group of patients that could benefit from cellular transplantation therapy designed with the aim of repair and regeneration of damaged spinal cord tissues.

Material and methods: Five years monocentric (Gui-de-Chauliac Hospital, Montpellier, France) retrospective analysis of patients suffering from spinal cord injury (SCI). Spinal cord injured-patients, defined as sensory-motor complete, underwent a clinical evaluation following American Spinal Injury Association (ASIA) and functional type 2 Spinal Cord Independence Measure (SCIM2) scorings as well as radiological evaluation through spinal cord magnetic resonance imaging (MRI).

Results: One hundred and fifty-seven medical records were reviewed and we selected and re-examined 20 patients with complete thoracic spinal cord lesion. Clinical and radiological evaluations of these patients demonstrated, in 75 % of the cases, an absence of clinical progression after a mean of 49months. Radiological abnormalities were constantly present in the initial (at the admission to hospital) and control (re-evaluation) MRI and no reliable predictive criteria of prognosis had been found.

Discussion/conclusion: We compare our results to the literature and discuss advantages and limits of cellular transplantation strategies for these patients.

MeSH terms

  • Acute Disease
  • Cell Transplantation
  • Humans
  • Magnetic Resonance Imaging
  • Prognosis
  • Radiography
  • Recovery of Function / physiology
  • Retrospective Studies
  • Spinal Cord Injuries / diagnostic imaging*
  • Spinal Cord Injuries / epidemiology*
  • Spinal Cord Injuries / therapy
  • Treatment Outcome