Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential

Pharmacol Ther. 2012 Dec;136(3):354-74. doi: 10.1016/j.pharmthera.2012.08.014. Epub 2012 Aug 29.


Heat shock cognate protein 70 (HSC70) is a constitutively expressed molecular chaperone which belongs to the heat shock protein 70 (HSP70) family. HSC70 shares some of the structural and functional similarity with HSP70. HSC70 also has different properties compared with HSP70 and other heat shock family members. HSC70 performs its full functions by the cooperation of co-chaperones. It interacts with many other molecules as well and regulates various cellular functions. It is also involved in various diseases and may become a biomarker for diagnosis and potential therapeutic targets for design, discovery, and development of novel drugs to treat various diseases. In this article, we provide a comprehensive review on HSC70 from the literatures including the basic general information such as classification, structure and cellular location, genetics and function, as well as its protein association and interaction with other proteins. In addition, we also discussed the relationship of HSC70 and related clinical diseases such as cancer, cardiovascular, neurological, hepatic and many other diseases and possible therapeutic potential and highlight the progress and prospects of research in this field. Understanding the functions of HSC70 and its interaction with other molecules will help us to reveal other novel properties of this protein. Scientists may be able to utilize this protein as a biomarker and therapeutic target to make significant advancement in scientific research and clinical setting in the future.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / drug therapy
  • Cardiovascular Diseases / etiology
  • Gene Expression Regulation
  • HSC70 Heat-Shock Proteins / analysis
  • HSC70 Heat-Shock Proteins / chemistry
  • HSC70 Heat-Shock Proteins / genetics
  • HSC70 Heat-Shock Proteins / physiology*
  • HSP70 Heat-Shock Proteins / physiology
  • Humans
  • Liver Diseases / drug therapy
  • Liver Diseases / etiology
  • Neoplasms / drug therapy
  • Neoplasms / etiology


  • HSC70 Heat-Shock Proteins
  • HSP70 Heat-Shock Proteins