Molecular aspects of vitamin D anticancer activity

Cancer Invest. 2012 Oct;30(8):604-14. doi: 10.3109/07357907.2012.721039. Epub 2012 Sep 10.

Abstract

Environment may influence the development and prevention of cancer. Calcitriol has been associated with calcium homeostasis regulation. Many epidemiological, biochemical, and genetic studies have shown non-classic effects of vitamin D, such as its involvement in the progression of different cancers. Although vitamin D induces cellular arrest, triggers apoptotic pathways, inhibits angiogenesis, and alters cellular adhesion, the precise mechanisms of its action are still not completely established. This article will present a revision about the molecular aspects proposed to be involved in the anticancer action of calcitriol. Adequate levels of vitamin D to prevent cancer development will also be discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / metabolism
  • Anti-Inflammatory Agents / pharmacology
  • Antineoplastic Agents / metabolism*
  • Antineoplastic Agents / pharmacology
  • Apoptosis / drug effects
  • Autophagy / drug effects
  • Calcitriol / metabolism
  • Calcitriol / pharmacology
  • Calcium Signaling / drug effects
  • Cell Adhesion Molecules / metabolism
  • Cell Cycle / drug effects
  • Cell Differentiation / drug effects
  • Humans
  • Neoplasms / genetics*
  • Neoplasms / metabolism*
  • Neoplasms / prevention & control
  • Neovascularization, Physiologic / drug effects
  • Polymorphism, Genetic
  • Reactive Oxygen Species / metabolism
  • Receptors, Calcitriol / genetics
  • Vitamin D / metabolism*
  • Vitamin D / pharmacology

Substances

  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Cell Adhesion Molecules
  • Reactive Oxygen Species
  • Receptors, Calcitriol
  • Vitamin D
  • Calcitriol