The dawn of angiogenesis modeling: regenerating vasculature from human pluripotent stem cells

Cell Res. 2013 Jan;23(1):3-5. doi: 10.1038/cr.2012.131. Epub 2012 Sep 11.


Efficient generation of functional human vascular endothelial cells and smooth muscle cells from pluripotent stem cells is an extensively studied topic and of great interest in the stem cell field. Though thought to be technically complex and difficult, substantial progress has been made towards this direction. Here we aim to summarize and discuss the most recent advances in this topic and their future perspective in research and clinic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Differentiation
  • Endothelial Cells / cytology
  • Humans
  • Models, Biological*
  • Myocytes, Smooth Muscle / cytology
  • Neovascularization, Physiologic / physiology*
  • Pluripotent Stem Cells / cytology*
  • Pluripotent Stem Cells / metabolism
  • Receptors, Urokinase Plasminogen Activator / metabolism
  • Regeneration


  • Receptors, Urokinase Plasminogen Activator