A chemically programmed antibody is a long-lasting and potent inhibitor of influenza neuraminidase

Chembiochem. 2012 Oct 15;13(15):2191-5. doi: 10.1002/cbic.201200439. Epub 2012 Sep 10.

Abstract

Programming an anti-flu strategy: A new and potent neuraminidase inhibitor that maintains long-term systemic exposure of an antibody and the therapeutic activity of the neuraminadase inhibitor zanamivir has been created. This strategy could provide a promising new class of influenza A drugs for therapy and prophylaxis, and validates enzyme inhibitors as programming agents in synthetic immunology.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antibodies, Monoclonal / chemistry*
  • Antibodies, Monoclonal / pharmacokinetics
  • Antibodies, Monoclonal / pharmacology
  • Antiviral Agents / chemistry*
  • Antiviral Agents / pharmacokinetics
  • Antiviral Agents / pharmacology
  • Click Chemistry
  • Fructose-Bisphosphate Aldolase / immunology
  • Humans
  • Immunoconjugates / chemistry*
  • Immunoconjugates / pharmacokinetics
  • Immunoconjugates / pharmacology
  • Influenza A virus / drug effects
  • Influenza A virus / enzymology*
  • Influenza, Human / drug therapy
  • Influenza, Human / virology
  • Mice
  • Models, Molecular
  • Neuraminidase / antagonists & inhibitors*
  • Neuraminidase / metabolism
  • Orthomyxoviridae Infections / drug therapy
  • Orthomyxoviridae Infections / virology
  • Zanamivir / chemistry*
  • Zanamivir / pharmacokinetics
  • Zanamivir / pharmacology

Substances

  • Antibodies, Monoclonal
  • Antiviral Agents
  • Immunoconjugates
  • Neuraminidase
  • Fructose-Bisphosphate Aldolase
  • Zanamivir