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, 2012, 709483

Antioxidant and Anti-Inflammatory Properties of Longan (Dimocarpus Longan Lour.) Pericarp

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Antioxidant and Anti-Inflammatory Properties of Longan (Dimocarpus Longan Lour.) Pericarp

Guan-Jhong Huang et al. Evid Based Complement Alternat Med.

Abstract

This study examined the antioxidant and anti-inflammatory activities of the water extract of longan pericarp (WLP). The results showed that WLP exhibited radical scavenging, reducing activity and liposome protection activity. In addition, WLP also inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production in macrophages. Further, administration of WLP, in the range of 100-400 mg/kg, showed a concentration-dependent inhibition on paw edema development following carrageenan (Carr) treatment in mice. The anti-inflammatory effects of WLP may be related to NO and tumor necrosis factor (TNF-α) suppression and associated with the increase in the activities of antioxidant enzymes, including catalase, superoxide dismutase, and glutathione peroxidase. Overall, the results showed that WLP might serve as a natural antioxidant and inflammatory inhibitor.

Figures

Figure 1
Figure 1
HPLC chromatograms of three markers (a) and water extract of longan pericarp (b) (1) gallic acid; (2) epicatechin; (3) ellagic acid; IS: butyl p-hydroxybenzoate.
Figure 2
Figure 2
Effects of WLP on cell viability (a), NO production (b), iNOS and COX-2 protein expressions (c), and relative iNOS and COX-2 protein levels (d) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The data were presented as mean ± SEM for three different experiments performed in triplicate. ### P < 0.001 as compared with control group. *P < 0.05, **P < 0.01, and ***P < 0.001 as compared with LPS alone group.
Figure 3
Figure 3
Effects of WLP and Indo on hind paw edema (a), the tissue MDA concentration of foot (b), serum NO (c), and TNF-α (d) concentrations of serum at the 5th h in Carr-induced mice. The data were presented as mean ± SEM for three different experiments performed in triplicate. ### P < 0.001 as compared with control group. *P < 0.05, **P < 0.01, and ***P < 0.001 as compared with Carr alone group.
Figure 4
Figure 4
Inhibition of iNOS and COX-2 protein expression of foot by WLP at the 5th hr in Carr-induced mice (a) β-Actin was used as an internal control. Relative iNOS and COX-2 protein levels were calculated with reference to Carr group (b) The data were presented as mean ± SEM for three different experiments performed in triplicate. ### P < 0.001  as compared with control group. ***P < 0.001 as compared with Carr alone group.

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