Breast disease: tissue characterization with Gd-DTPA enhancement profiles

Radiology. 1990 Feb;174(2):491-4. doi: 10.1148/radiology.174.2.2296657.


Magnetic resonance (MR) imaging of the breast is currently of limited value because of lack of specificity. Enhanced MR imaging with gadolinium diethylenetriaminepentaacetic acid (DTPA) has been shown to be helpful in the further characterization of breast tissue. This prospective study attempted to differentiate benign and malignant breast disease with a dynamic enhancement technique. Bolus injection of Gd-DTPA and a short MR imaging time were used to examine 18 patients with a palpable breast mass. Construction of enhancement profiles helped effectively differentiate benign and malignant lesion (P less than .001). Dynamic MR imaging shows promise for the further characterization of breast tissue and, particularly, identification of breast carcinoma.

MeSH terms

  • Adult
  • Aged
  • Breast Diseases / diagnosis*
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / pathology
  • Carcinoma / diagnosis
  • Carcinoma / pathology
  • Contrast Media* / administration & dosage
  • Female
  • Fibrocystic Breast Disease / diagnosis
  • Fibrocystic Breast Disease / pathology
  • Gadolinium DTPA
  • Gadolinium* / administration & dosage
  • Humans
  • Image Enhancement
  • Magnetic Resonance Imaging* / methods
  • Middle Aged
  • Organometallic Compounds* / administration & dosage
  • Pentetic Acid* / administration & dosage
  • Time Factors


  • Contrast Media
  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium
  • Gadolinium DTPA