A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

Science. 1990 Jan 19;247(4940):322-4. doi: 10.1126/science.2296722.

Abstract

In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to spontaneous intestinal cancer. The mutant gene was found to be dominantly expressed and fully penetrant. Affected mice developed multiple adenomas throughout the entire intestinal tract at an early age.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenoma / complications
  • Adenoma / genetics*
  • Alleles
  • Anemia / complications
  • Anemia / genetics
  • Animals
  • Ethylnitrosourea
  • Female
  • Intestinal Neoplasms / complications
  • Intestinal Neoplasms / genetics*
  • Intestinal Neoplasms / pathology
  • Male
  • Mice
  • Mice, Inbred AKR
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Mutation*

Substances

  • Ethylnitrosourea