Abstract
It is becoming increasingly clear that gene-environment interactions are risk factors for autism. However, there is limited information regarding the susceptibility of specific autism candidate genes to dysregulation by environmental factors, and even less information on the types of environmental agents that may lead to increased risk for autism. Based on our published studies, I propose that the demonstrated responsiveness of RORA to sex hormones makes it a prime target for disruption by endocrine disrupting compounds.
Copyright © 2012 Elsevier Inc. All rights reserved.
MeSH terms
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Animals
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Autistic Disorder / chemically induced*
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Autistic Disorder / genetics*
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Autistic Disorder / metabolism
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Autistic Disorder / physiopathology
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Autistic Disorder / psychology
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Behavior, Animal
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Brain / drug effects*
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Brain / growth & development
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Brain / metabolism
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Brain / physiopathology
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Disease Models, Animal
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Endocrine Disruptors / adverse effects*
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Female
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Gene-Environment Interaction*
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Genetic Predisposition to Disease
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Gonadal Steroid Hormones / metabolism
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Humans
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Male
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Mice
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Mice, Knockout
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Nuclear Receptor Subfamily 1, Group F, Member 1 / deficiency
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Nuclear Receptor Subfamily 1, Group F, Member 1 / drug effects*
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Nuclear Receptor Subfamily 1, Group F, Member 1 / genetics*
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Nuclear Receptor Subfamily 1, Group F, Member 1 / metabolism
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Risk Factors
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Sex Characteristics
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Sex Factors
Substances
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Endocrine Disruptors
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Gonadal Steroid Hormones
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Nuclear Receptor Subfamily 1, Group F, Member 1
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RORA protein, human
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Rora protein, mouse