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. 2012 Oct;23(9-10):580-6.
doi: 10.1007/s00335-012-9422-2. Epub 2012 Sep 12.

The Mammalian Gene Function Resource: The International Knockout Mouse Consortium

Free PMC article

The Mammalian Gene Function Resource: The International Knockout Mouse Consortium

Allan Bradley et al. Mamm Genome. .
Free PMC article


In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal ( has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.


Fig. 1
Fig. 1
Vectors used by the IKMC: targeting vectors: a EUCOMM/KOMP-CSD knockout-first allele; b KOMP-Regeneron null allele generating large deletions; c NorCOMM promoter-driven targeting vector. Most commonly used trapping vectors: d conditional EUCOMM vector rsFlipROSAβgeo*; e TIGM vector VICTR76; f NorCOMM vector UPA

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