Rosette-forming glioneuronal tumor -- evidence of stem cell origin with biphenotypic differentiation

Virchows Arch. 2012 Nov;461(5):581-8. doi: 10.1007/s00428-012-1313-0. Epub 2012 Sep 13.


Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a new addition to the WHO classification of central nervous system tumors. To date, 72 cases have been described in literature. In the present study, we report the clinical and imaging features, with detailed histopathological and immunohistochemical profile, of eight cases. Confocal microscopic evidence of stem cell origin with biphenotypic, glial and neurocytic differentiation is presented with a comprehensive review of literature.

Publication types

  • Multicenter Study
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Biomarkers, Tumor / metabolism
  • Brain Neoplasms / metabolism
  • Brain Neoplasms / pathology*
  • Child
  • Female
  • Ganglioglioma / metabolism
  • Ganglioglioma / pathology*
  • Humans
  • Immunoenzyme Techniques
  • Magnetic Resonance Imaging
  • Male
  • Microscopy, Confocal
  • Middle Aged
  • Neoplastic Stem Cells / metabolism
  • Neoplastic Stem Cells / pathology*
  • Phenotype
  • Young Adult


  • Biomarkers, Tumor