Dental composites and amalgam and physical development in children

J Dent Res. 2012 Nov;91(11):1019-25. doi: 10.1177/0022034512458691. Epub 2012 Sep 12.

Abstract

Resin-based composite dental restoration materials may release bisphenol-A, an endocrine-disrupting chemical. Using secondary analysis of a randomized clinical safety trial of amalgam vs. composites, we tested the hypothesis that dental restoration materials affect children's growth. Children (N = 218 boys, N = 256 girls) aged 6 to 10 yrs at baseline with ≥ 2 decayed posterior teeth were randomized to amalgam or composites (bisphenol-A-diglycidyl-dimethacrylate composite for permanent teeth, urethane-dimethacrylate compomer for primary teeth) for treatment of posterior caries throughout follow-up. Primary outcomes for this analysis were 5-year changes in BMI-for-age z-scores, body fat percentage (BF%), and height velocity; exploratory analyses (n = 113) examined age at menarche. Results showed no significant differences between treatment assignment and changes in physical development in boys [(composites vs. amalgam) BF%, 4.9 vs. 5.7, p = 0.49; (BMI-z-score) 0.13 vs. 0.25, p = 0.36] or girls (8.8 vs. 7.7, p = 0.95; 0.36 vs. 0.21, p = 0.49). Children with more treatment on primary teeth had greater increases in BF% regardless of material type. Girls assigned to composites had lower risk of menarche during follow-up (hazard ratio = 0.57, 95% CI 0.35-0.95). Overall, there were no significant differences in physical development over 5 years in children treated with composites or amalgam. Additional studies examining these restoration materials in relation to age at menarche are warranted (clinicaltrials.gov number NCT00065988).

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / drug effects
  • Analysis of Variance
  • Benzhydryl Compounds
  • Body Height / drug effects
  • Body Mass Index
  • Child
  • Child Development / drug effects*
  • Composite Resins / adverse effects*
  • Composite Resins / chemistry
  • Dental Amalgam / adverse effects*
  • Dental Restoration, Permanent / adverse effects*
  • Dental Restoration, Permanent / methods
  • Estrogens, Non-Steroidal / adverse effects*
  • Female
  • Humans
  • Linear Models
  • Male
  • Menarche / drug effects
  • Methacrylates / adverse effects
  • Phenols / adverse effects*
  • Polyurethanes / adverse effects
  • Sex Factors

Substances

  • Benzhydryl Compounds
  • Composite Resins
  • Estrogens, Non-Steroidal
  • Methacrylates
  • Phenols
  • Polyurethanes
  • urethane dimethacrylate luting resin
  • Dental Amalgam
  • bisphenol A

Associated data

  • ClinicalTrials.gov/NCT00065988