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Review
. 2012:46:499-513.
doi: 10.1146/annurev-genet-110711-155550. Epub 2012 Sep 4.

Neural regeneration in Caenorhabditis elegans

Rachid El Bejjani  1 , Marc Hammarlund
Affiliations
Review

Neural regeneration in Caenorhabditis elegans

Rachid El Bejjani et al. Annu Rev Genet. 2012.

Abstract

Axon regeneration is a medically relevant process that can repair damaged neurons. This review describes current progress in understanding axon regeneration in the model organism Caenorhabditis elegans. Factors that regulate axon regeneration in C. elegans have broadly similar roles in vertebrate neurons. This means that using C. elegans as a tool to leverage discovery is a legitimate strategy for identifying conserved mechanisms of axon regeneration.

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Figures

Figure 1
Figure 1
(a) A regenerating Caenorhabditis elegans GABA (γ-aminobutyric acid) neuron after laser surgery, and (b) a neuron that has failed to respond to injury (21).
Figure 2
Figure 2
Diagram of mitogen-activated protein kinase signaling during regeneration in Caenorhabditis elegans. Adapted from , .
See this image and copyright information in PMC

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