Febrile seizures and measles-mumps-rubella-varicella (MMRV) vaccine: what do primary care physicians think?

Vaccine. 2012 Nov 6;30(48):6731-3. doi: 10.1016/j.vaccine.2012.08.075. Epub 2012 Sep 10.


Purpose: Measles-mumps-rubella-varicella (MMRV) vaccine is associated with increased febrile seizure risk compared with measles-mumps-rubella and varicella vaccine given separately (MMR+V) in children 12-15-month old. We assessed knowledge regarding MMRV and febrile seizures, intended practices, and factors influencing the decision to recommend MMRV.

Methods: National survey administered 10/2008-1/2009 of US pediatricians (Peds) and family physicians (FP).

Results: Response rate was 73% (620/849). Twenty-nine percent of Peds and 74% of FP (p<0.001) were unaware of increased febrile seizure risk after MMRV. After reading an informational statement, 20% of Peds and 7% of FP (p<0.001) would recommend MMRV to a healthy 12-15-month-old child. The factor most frequently reported as "very important" in the decision to recommend MMRV or MMR+V was ACIP/AAFP/AAP recommendations (pediatricians, 77%, family physicians, 73%, p=0.08).

Conclusions: After receiving data regarding febrile seizure risk after MMRV, few physicians report they would recommend MMRV to a healthy 12-15-month-old child.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chickenpox Vaccine / administration & dosage
  • Chickenpox Vaccine / adverse effects*
  • Child
  • Child, Preschool
  • Health Knowledge, Attitudes, Practice*
  • Humans
  • Infant
  • Measles-Mumps-Rubella Vaccine / administration & dosage
  • Measles-Mumps-Rubella Vaccine / adverse effects*
  • Physicians, Primary Care*
  • Seizures, Febrile / chemically induced*
  • Surveys and Questionnaires
  • Vaccination / methods*
  • Vaccination / statistics & numerical data
  • Vaccines, Combined / administration & dosage
  • Vaccines, Combined / adverse effects


  • Chickenpox Vaccine
  • Measles-Mumps-Rubella Vaccine
  • Vaccines, Combined
  • measles, mumps, rubella, varicella vaccine