Strategies for p53 reactivation in human sarcoma

Cancer Cell. 2012 Sep 11;22(3):283-5. doi: 10.1016/j.ccr.2012.08.020.


Emerging strategies in cancer therapeutics link the genomic mutational and proteomic landscape, allowing intelligent reasoning on target selection. In this issue of Cancer Cell, Piccinin and colleagues use this approach to demonstrate that the mesenchymal protein Twist1 inhibits p53, providing a novel target for reactivation of p53 in human sarcoma.

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