Interactions between HIV-1 and innate immunity in dendritic cells

Adv Exp Med Biol. 2013;762:183-200. doi: 10.1007/978-1-4614-4433-6_7.

Abstract

Dendritic cells couple pathogen sensing with induction of innate and adaptive immune responses. Pathogen sensing in dendritic cells relies on interactions between molecular patterns of the pathogens and germline-encoded, also referred to as innate, receptors. In this chapter, we analyze some of the interactions between HIV-1 and the innate immune system in dendritic cells. The HIV-1 replication cycle is constituted by an extracellular and an intracellular phase. The two phases of the cycle provide distinct opportunities for interactions with cell-extrinsic and cell-intrinsic mechanisms in dendritic cells. According to the types of dendritic cells, the mechanisms of innate interactions between dendritic cells and HIV-1 lead to specific responses. These innate interactions may contribute to influencing and shaping the adaptive immune response against the virus.

Publication types

  • Review

MeSH terms

  • Dendritic Cells / immunology*
  • HIV-1 / immunology
  • HIV-1 / physiology*
  • Humans
  • Immunity, Innate*
  • Virus Replication