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Randomized Controlled Trial
. 2013 Mar;113(3):793-802.
doi: 10.1007/s00421-012-2492-8. Epub 2012 Sep 14.

Betaine Supplementation Enhances Anabolic Endocrine and Akt Signaling in Response to Acute Bouts of Exercise

Affiliations
Randomized Controlled Trial

Betaine Supplementation Enhances Anabolic Endocrine and Akt Signaling in Response to Acute Bouts of Exercise

Jenna M Apicella et al. Eur J Appl Physiol. .

Abstract

Our aim was to examine the effect of betaine supplementation on selected circulating hormonal measures and Akt muscle signaling proteins after an acute exercise session. Twelve trained men (age 19.7 ± 1.23 years) underwent 2 weeks of supplementation with either betaine (B) (1.25 g BID) or placebo (P). Following a 2-week washout period, subjects underwent supplementation with the other treatment (B or P). Before and after each 2-week period, subjects performed an acute exercise session (AES). Circulating GH, IGF-1, cortisol, and insulin were measured. Vastus lateralis samples were analyzed for signaling proteins (Akt, p70 S6k, AMPK). B (vs. P) supplementation approached a significant increase in GH (mean ± SD (Area under the curve, AUC), B: 40.72 ± 6.14, P: 38.28 ± 5.54, p = 0.060) and significantly increased IGF-1 (mean ± SD (AUC), B: 106.19 ± 13.45, P: 95.10 ± 14.23, p = 0.010), but significantly decreased cortisol (mean ± SD (AUC), B: 1,079.18 ± 110.02, P: 1,228.53 ± 130.32, p = 0.007). There was no difference in insulin (AUC). B increased resting Total muscle Akt (p = 0.003). B potentiated phosphorylation (relative to P) of Akt (Ser(473)) and p70 S6 k (Thr(389)) (p = 0.016 and p = 0.005, respectively). Phosphorylation of AMPK (Thr(172)) decreased during both treatments (both p = 0.001). Betaine (vs. placebo) supplementation enhanced both the anabolic endocrine profile and the corresponding anabolic signaling environment, suggesting increased protein synthesis.

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References

    1. Acta Physiol Scand. 1994 Jul;151(3):413-6 - PubMed
    1. J Endocrinol. 1994 Jun;141(3):517-25 - PubMed
    1. Nutr Res Rev. 2005 Jun;18(1):31-48 - PubMed
    1. Ann Intern Med. 2008 May 20;148(10):747-58 - PubMed
    1. Sports Med. 2008;38(7):527-40 - PubMed

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