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Randomized Controlled Trial
. 2012 Sep;61(9):381-98.

Effect of Subgingival Application of Topical Ozonated Olive Oil in the Treatment of Chronic Periodontitis: A Randomized, Controlled, Double Blind, Clinical and Microbiological Study

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  • PMID: 22976566
Randomized Controlled Trial

Effect of Subgingival Application of Topical Ozonated Olive Oil in the Treatment of Chronic Periodontitis: A Randomized, Controlled, Double Blind, Clinical and Microbiological Study

P V Patel et al. Minerva Stomatol. .

Abstract

Aim: The aim of this paper was to evaluate the efficacy of ozonated olive oil as a monotherapy and an adjunct to scaling and root planing in the treatment of chronic periodontitis

Methods: A split mouth, double-blinded, randomized controlled clinical trial was conducted on 20 subjects diagnosed with chronic periodontitis. Quadrants of each subject were randomly assigned to four groups and treated accordingly: Group A, scaling and root planing (SRP): Group B, topical ozonated olive oil (OZO) as an adjunct to scaling and root planing: Group C, topical ozonated olive oil as a monotherapy and: Group D, topical chlorhexidine gel as a monotherapy. The quadrants were analyzed clinically by plaque index, gingival index, sulcus bleeding index, probing pocket depth, and clinical attachment level at baseline, 2, 4, 6 and 8 weeks of time intervals. The subjects were also analyzed for perceived pain, discomfort or tooth hypersensitivity (quadrant wise) on a Visual Analogue Scale (VAS). Additionally, subgingival plaque samples were collected from the two predetermined sites of each quadrant at baseline, 4 and 8 weeks for the analysis of total bacterial counts (TBCs) and the detection of frequency of eight putative periodontopathogens by polymerase chain reaction (PCR) method.

Results: The adjunctive use of the OZO with SRP resulted in a significant improvement (P<0.001) of clinical parameters as well as microbiological parameters over the time and in comparison to the control groups. The OZO as monotherapy also showed a significant improvement (P<0.001) in clinical parameters as well as microbiological parameters over the time without any documented side effects. However, there was a significant increase (P<0.05) in dentinal hypersensitivity following OZO as an adjunct to scaling and root planing therapy.

Conclusion: The OZO, as an adjunctive therapy as well as a mono-therapy is efficient in improving periodontal conditions.

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