Extraneural ependymoma: distant bone, lung, liver, and lymph node metastases following bevacizumab

Pediatr Blood Cancer. 2013 Jan;60(1):143-5. doi: 10.1002/pbc.24268. Epub 2012 Sep 13.


Extraneural metastases of ependymoma are rare, and have been reported in the lungs, lymph nodes, pleura, mediastinum, liver, diaphragmatic muscle, and bone. We report a case of anaplastic ependymoma with distant metastases to the vertebral bones, lungs, liver, and lymph nodes following treatment with bevacizumab. Recent research has hypothesized that angiogenic tumors may develop means of resistance to antiangiogenic therapies, and some evidence suggests potential for antiangiogenic therapies to promote additional means for cancer spread. Nevertheless, antiangiogenic therapies continue to demonstrate potential as potent therapies for the treatment of many cancers, and should continue to be researched for future uses.

Publication types

  • Case Reports

MeSH terms

  • Angiogenesis Inhibitors / therapeutic use*
  • Antibodies, Monoclonal, Humanized / therapeutic use*
  • Bevacizumab
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / pathology
  • Child
  • Ependymoma / drug therapy*
  • Ependymoma / secondary
  • Female
  • Humans
  • Liver Neoplasms / secondary*
  • Lung Neoplasms / secondary*
  • Lymphatic Metastasis
  • Spinal Neoplasms / secondary*


  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal, Humanized
  • Bevacizumab