Cerebral metastasis of cervical cancer, report of two cases and review of the literature

Int J Clin Exp Pathol. 2012;5(7):710-4. Epub 2012 Sep 5.


Cervical cancers spread locally through the angiolymphatic apparatus and very rarely metastasize to the brain. The intracranial metastasis is a late event and a sign of poor prognosis. We present two cases of uterine cervical carcinomas with brain metastasis presenting with severe headaches in one case and hemiparesis and aphasia in the other one. Palliative craniotomy and debulking of the tumor was performed in both patients.

Keywords: Cervical cancer; brain metastases; carcinoma of uterine cervix; intracranial metastasis; metastatic cervical cancer.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenocarcinoma / metabolism
  • Adenocarcinoma / secondary*
  • Adenocarcinoma / therapy
  • Adult
  • Biomarkers, Tumor / metabolism
  • Brain Neoplasms / metabolism
  • Brain Neoplasms / secondary*
  • Brain Neoplasms / therapy
  • Cerebrum / pathology*
  • Combined Modality Therapy
  • Craniotomy
  • Fatal Outcome
  • Female
  • Humans
  • Middle Aged
  • Palliative Care / methods
  • Prognosis
  • Uterine Cervical Neoplasms / metabolism
  • Uterine Cervical Neoplasms / pathology*
  • Uterine Cervical Neoplasms / therapy


  • Biomarkers, Tumor