Everolimus-induced pneumonitis after drug-eluting stent implantation: a case report

Cardiovasc Intervent Radiol. 2013 Aug;36(4):1151-4. doi: 10.1007/s00270-012-0477-y. Epub 2012 Sep 15.

Abstract

Despite the wide use of everolimus as an antineoplastic coating agent for coronary stents to reduce the rate of restenosis, little is known about the health hazards of everolimus-eluting stents (EES). We describe a case of pneumonitis that developed 2 months after EES implantation for angina. Lung pathology demonstrated an organizing pneumonia pattern that responded to corticosteroid therapy. Although the efficacy of EES for ischemic heart disease is well established, EES carries a risk of pneumonitis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Angina Pectoris / diagnostic imaging
  • Angina Pectoris / therapy
  • Angioplasty, Balloon, Coronary / adverse effects*
  • Angioplasty, Balloon, Coronary / methods
  • Coronary Restenosis / diagnostic imaging
  • Coronary Restenosis / therapy*
  • Coronary Stenosis / diagnostic imaging
  • Coronary Stenosis / therapy
  • Drug-Eluting Stents / adverse effects*
  • Everolimus
  • Follow-Up Studies
  • Humans
  • Male
  • Paclitaxel / therapeutic use
  • Pneumonia / diagnostic imaging
  • Pneumonia / drug therapy
  • Pneumonia / etiology*
  • Prednisolone / therapeutic use
  • Radiography, Thoracic
  • Retreatment
  • Risk Assessment
  • Sirolimus / administration & dosage
  • Sirolimus / adverse effects
  • Sirolimus / analogs & derivatives*
  • Tomography, X-Ray Computed / methods
  • Treatment Outcome

Substances

  • Everolimus
  • Prednisolone
  • Paclitaxel
  • Sirolimus