Revisiting an old riddle: what determines genetic diversity levels within species?

PLoS Biol. 2012;10(9):e1001388. doi: 10.1371/journal.pbio.1001388. Epub 2012 Sep 11.


Understanding why some species have more genetic diversity than others is central to the study of ecology and evolution, and carries potentially important implications for conservation biology. Yet not only does this question remain unresolved, it has largely fallen into disregard. With the rapid decrease in sequencing costs, we argue that it is time to revive it.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosomes, Insect / genetics
  • Drosophila / genetics*
  • Ecosystem
  • Genetic Variation*
  • Geography
  • Models, Biological
  • Nucleotides / genetics
  • Phylogeny
  • Selection, Genetic
  • Sex Chromosomes / genetics
  • Species Specificity


  • Nucleotides