Interplay between vitamin D and the drug metabolizing enzyme CYP3A4

J Steroid Biochem Mol Biol. 2013 Jul;136:54-8. doi: 10.1016/j.jsbmb.2012.09.012. Epub 2012 Sep 15.

Abstract

Cytochrome P450 3A4 (CYP3A4) is a multifunctional enzyme involved in both xenobiotic and endobiotic metabolism. This review focuses on two aspects: regulation of CYP3A4 expression by vitamin D and metabolism of vitamin D by CYP3A4. Enterohepatic circulation of vitamin D metabolites and their conjugates will be also discussed. The interplay between vitamin D and CYP3A4 provides new insights into our understanding of how enzyme induction can contribute to vitamin D deficiency. This article is part of a Special Issue entitled 'Vitamin D Workshop'.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Biotransformation
  • Cytochrome P-450 CYP3A / metabolism*
  • Enterohepatic Circulation
  • Enzyme Induction / physiology
  • Humans
  • Models, Biological
  • Vitamin D / pharmacokinetics*
  • Vitamin D Deficiency / etiology

Substances

  • Vitamin D
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human