PAF antagonist ginkgolide B reduces postischemic neuronal damage in rat brain hippocampus

J Cereb Blood Flow Metab. 1990 Jan;10(1):133-5. doi: 10.1038/jcbfm.1990.17.


We investigated the effect of the known antagonist of platelet-activating factor (PAF), ginkgolide B, on postischemic neuronal damage in the rat. Neuronal necroses were evaluated in the hippocampus 7 days after a 10-min forebrain ischemia. Preischemic application of ginkgolide B (50 mg/kg p.o.) significantly reduced neuronal damage. It is suggested that the antagonism of PAF is responsible for this beneficial effect of ginkgolide B.

MeSH terms

  • Animals
  • Brain Ischemia / pathology*
  • Cell Survival / drug effects
  • Diterpenes*
  • Ginkgolides
  • Hippocampus / pathology*
  • Lactones / pharmacology*
  • Male
  • Necrosis
  • Neurons / pathology*
  • Plant Extracts
  • Platelet Activating Factor / antagonists & inhibitors*
  • Rats
  • Rats, Inbred Strains


  • Diterpenes
  • Ginkgolides
  • Lactones
  • Plant Extracts
  • Platelet Activating Factor
  • ginkgolide B