Legg-Calvé-Perthes disease in hemophilia: incidence and etiologic considerations

J Pediatr Orthop. 1990 Jan-Feb;10(1):28-32.

Abstract

A review of hip radiographs of patients with severe hemophilia showed Legg-Calvé-Perthes disease in four of 63 patients examined before the era of specific treatment. In another series of 44 patients receiving prophylactic treatment, there was no evidence of Legg-Calvé-Perthes disease. A case report of a boy with severe hemophilia with hip joint bleeding that caused joint capsule distention and greatly increased intracapsular pressure is presented. Based on our findings, and previously published results, we suggest that Legg-Calvé-Perthes disease in hemophilia is caused by increased intracapsular pressure secondary to hemarthrosis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Biomechanical Phenomena
  • Child
  • Child, Preschool
  • Femur Head Necrosis / epidemiology*
  • Hemophilia A / complications*
  • Hemophilia A / drug therapy
  • Humans
  • Incidence
  • Legg-Calve-Perthes Disease / diagnostic imaging
  • Legg-Calve-Perthes Disease / epidemiology*
  • Legg-Calve-Perthes Disease / etiology
  • Male
  • Pressure
  • Tomography, X-Ray Computed