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. 2012 Sep 18;17(9):11146-55.
doi: 10.3390/molecules170911146.

Antitrypanosomal alkaloids from the marine bacterium Bacillus pumilus

Sergio Martínez-Luis  1 , José Félix Gómez, Carmenza Spadafora, Héctor M Guzmán, Marcelino Gutiérrez
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Free PMC article

Antitrypanosomal alkaloids from the marine bacterium Bacillus pumilus

Sergio Martínez-Luis et al. Molecules. .
Free PMC article

Abstract

Fractionation of the ethyl acetate extract of the marine bacterium Bacillus pumilus isolated from the black coral Antipathes sp. led to the isolation of five compounds: cyclo-(L-Leu-L-Pro) (1), 3-hydroxyacetylindole (2), N-acetyl-β-oxotryptamine (3), cyclo-(L-Phe-L-Pro) (4), and 3-formylindole (5). The structures of compounds 1-5 were established by spectroscopic analyses, including HRESITOF-MS and NMR (1H, 13C, HSQC, HMBC and COSY). Compounds 2, 3 and 5 caused the inhibition on the growth of Trypanosoma cruzi (T. cruzi), with IC50 values of 20.6, 19.4 and 26.9 μM, respectively, with moderate cytotoxicity against Vero cells. Compounds 1-5 were found to be inactive when tested against Plasmodium falciparum and Leishmania donovani, therefore showing selectivity against T. cruzi parasites.

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Figure 1
Figure 1
Chemical structuresof metabolitesproduced by Bacillus pumilus.
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