Abstract
The Pd-catalyzed asymmetric allylic alkylation (AAA) reaction of nitromethane with monosubstituted allyl substrates was realized for the first time to provide corresponding products in high yields with excellent regio- and enantioselectivities. The protocol was applied to the enantioselective synthesis of (R)-baclofen and (R)-rolipram.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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Allyl Compounds / chemistry*
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Baclofen / chemical synthesis*
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Baclofen / chemistry
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Catalysis
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Methane / analogs & derivatives*
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Methane / chemistry
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Molecular Structure
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Nitroparaffins / chemistry*
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Organometallic Compounds / chemistry*
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Palladium / chemistry*
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Rolipram / chemical synthesis*
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Rolipram / chemistry
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Stereoisomerism
Substances
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Allyl Compounds
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Nitroparaffins
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Organometallic Compounds
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Palladium
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Baclofen
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Rolipram
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Methane
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nitromethane