TGFβ Signalling in Context

Nat Rev Mol Cell Biol. 2012 Oct;13(10):616-30. doi: 10.1038/nrm3434. Epub 2012 Sep 20.

Abstract

The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed more than a decade ago. Since then, the concept of how the TGFβ signal travels from the membrane to the nucleus has been enriched with additional findings, and its multifunctional nature and medical relevance have relentlessly come to light. However, an old mystery has endured: how does the context determine the cellular response to TGFβ? Solving this question is key to understanding TGFβ biology and its many malfunctions. Recent progress is pointing at answers.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism
  • Cell Nucleus / metabolism
  • Chromatin / metabolism
  • Epithelial-Mesenchymal Transition
  • Humans
  • Neoplasms / metabolism
  • Phosphorylation
  • Receptors, Transforming Growth Factor beta / metabolism*
  • Signal Transduction*
  • Smad Proteins / metabolism
  • Transforming Growth Factor beta / metabolism*

Substances

  • Chromatin
  • Receptors, Transforming Growth Factor beta
  • Smad Proteins
  • Transforming Growth Factor beta