Multifocal micronodular pneumocyte hyperplasia: computed tomographic appearance and follow-up in tuberous sclerosis complex

J Comput Assist Tomogr. Sep-Oct 2012;36(5):518-22. doi: 10.1097/RCT.0b013e318264e404.

Abstract

Objective: To characterize pulmonary nodules in patients with tuberous sclerosis complex (TSC) using computed tomography.

Methods: We retrospectively reviewed chest computed tomographic images of 73 patients with TSC (22 males and 51 females; mean ± SD age, 31.5 ± 13.2 years; range, 13.8-63.5 years).

Results: Multiple pulmonary nodules were identified in 42 (58%) of 73 patients (mean ± SD size, 6.6 ± 3.0 mm; range, 2-14 mm). Solid nodules were present in 11 (26%) of 42 patients, ground-glass nodules were present in 3 (7%) of 42 patients, and both solid and ground-glass nodules were present in 28 (67%) of 42 patients. The presence of multiple nodules was independent of sex and lymphangioleiomyomatosis. Follow-up images were available for 22 patients with multiple nodules (mean ± SD follow-up, 2.0 ± 1.1 years; range, 0.9-4.9 years), none of whom had change in nodule size or number.

Conclusions: Most men and women with TSC have multiple pulmonary nodules, which likely represent multifocal micronodular pneumocyte hyperplasia in the absence of known predisposing factors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Algorithms
  • Alveolar Epithelial Cells / diagnostic imaging*
  • Chi-Square Distribution
  • Contrast Media
  • Female
  • Humans
  • Hyperplasia / diagnostic imaging
  • Iopamidol
  • Male
  • Middle Aged
  • Multiple Pulmonary Nodules / diagnostic imaging*
  • Radiographic Image Interpretation, Computer-Assisted
  • Radiography, Thoracic / methods
  • Respiratory Function Tests
  • Retrospective Studies
  • Tomography, X-Ray Computed / methods*
  • Tuberous Sclerosis / diagnostic imaging*

Substances

  • Contrast Media
  • Iopamidol