Elution of TEGDMA and HEMA from polymerized resin-based bonding systems

Dent Mater. 2012 Nov;28(11):1120-5. doi: 10.1016/j.dental.2012.06.010. Epub 2012 Sep 18.


Objectives: In this study the amount of TEGDMA and HEMA eluted from several adhesive systems was quantified.

Methods: The adhesive systems were applied according to manufacturers' instructions in an analytic vial. The adhesive systems used were (abbreviation and producer in parenthesis): cmf adhesive system(®) (CMF) (Saremco), ENAbond (EB) (Micerium), Optibond FL (OB) (Kerr), Adper Scotchbond Multi-Purpose (SB) (3M ESPE), Silorane System Adhesive (SSA) (3M ESPE), Syntac Classic (SC) (Ivoclar Vivadent) and XP Bond (XPB) (Dentsply). After preparation the specimens were immersed in methanol or distilled water for a period from 1d to 30d at 37°C. Eluted TEGDMA and HEMA were determined by gas chromatographic-mass spectrometry (GC-MS).

Results: Following TEGDMA elution from adhesives was found (μg/ml; mean and standard deviation(sd); 1d/30d; methanol): SC 0.93(0.8)/0.68(0.5), SSA 0.27(0.09)/0.16(0.04) and XPB 0.25(0.1)/0.19(0.09). TEGDMA eluted from EB, CMF, OB, and SB was always below detection limit. TEGDMA water elution from each adhesive was about 1/5 lower, compared to the corresponding TEGDMA methanol elution. Following HEMA elution was found (μg/ml; mean(sd); 1d/30d; methanol): SB 3.42(0.9)/2.02(1.2), EB 3.07(2.2)/2.15(2.2), XPB 2.47(1.6)/1.89(1.1), OB 1.4(0.7)/0.82(0.2) and SSA 0.44(0.2)/0.17(0.07). HEMA eluted from CMF and SC was always below detection limit. HEMA water elution from each adhesive was about 1/10 lower, compared to the corresponding HEMA methanol elution.

Significance: SC, SSA, and XPB eluted TEGDMA. SB, EB, XPB, OB, and SSA eluted HEMA. CMF eluted neither HEMA nor TEGDMA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Composite Resins / chemistry*
  • Dentin Permeability
  • Dentin-Bonding Agents / chemistry*
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Methacrylates / analysis*
  • Polyethylene Glycols / analysis*
  • Polymerization
  • Polymethacrylic Acids / analysis*
  • Resin Cements / chemistry*
  • Silorane Resins / chemistry


  • Composite Resins
  • Dentin-Bonding Agents
  • Methacrylates
  • Polymethacrylic Acids
  • Resin Cements
  • Silorane Resins
  • triethylene glycol dimethacrylate
  • Polyethylene Glycols
  • hydroxyethyl methacrylate