Severe anaphylaxis caused by orally administered vancomycin to a patient with Clostridium difficile infection

D Bossé; C Lemire; J Ruel; A M Cantin; F Ménard; L Valiquette

doi:10.1007/s15010-012-0328-4

Severe anaphylaxis caused by orally administered vancomycin to a patient with Clostridium difficile infection

Infection. 2013 Apr;41(2):579-82. doi: 10.1007/s15010-012-0328-4. Epub 2012 Sep 21.

Authors

D Bossé¹, C Lemire, J Ruel, A M Cantin, F Ménard, L Valiquette

Affiliation

¹ Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC, Canada. dominick.bosse@usherbrooke.ca

PMID: 22996384
DOI: 10.1007/s15010-012-0328-4

Abstract

We report the first case of anaphylaxis to oral vancomycin in a cystic fibrosis patient with severe and relapsing Clostridium difficile infection (CDI) refractory to metronidazole. The patient's colitis has been successfully treated with a combination of intravenous metronidazole and tigecycline.

Publication types

Case Reports

MeSH terms

Administration, Oral
Adult
Anaphylaxis / chemically induced*
Anti-Bacterial Agents / adverse effects*
Anti-Bacterial Agents / therapeutic use
Clostridioides difficile
Clostridium Infections / drug therapy*
Cystic Fibrosis / complications
Diarrhea / microbiology
Enterocolitis, Pseudomembranous / drug therapy
Humans
Male
Metronidazole / therapeutic use
Minocycline / analogs & derivatives
Minocycline / therapeutic use
Severity of Illness Index
Tigecycline
Vancomycin / adverse effects*

Substances

Anti-Bacterial Agents
Metronidazole
Vancomycin
Tigecycline
Minocycline