Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoids, and their synthetic derivatives

Bioorg Khim. 2012 May-Jun;38(3):374-81. doi: 10.1134/s1068162012030028.

Abstract

Accessible triterpenoids of ursane and lupane series, the flavonoid dihydroquercetin and their synthetic derivatives with polar substituentss were tested in vitro for inhibition of collagenase 1 (MMP-1) in UVB irradiation assay. Ursolic acid and uvaol disuccinate were the most active inhibitors in the ursane series. In the lupane series, the best inhibition was manifested by carboxymethyl ester of betulonic acid and betulin succinates. Down- regulation of MMP-1 by dihydroquercetin and its synthetic derivatives surpassed the activity of a standard (retinoic acid).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Cell Line
  • Fibroblasts / drug effects
  • Humans
  • Interleukin-8 / antagonists & inhibitors
  • Keratinocytes / drug effects
  • Matrix Metalloproteinase 1
  • Oleanolic Acid / analogs & derivatives
  • Oleanolic Acid / chemistry
  • Oleanolic Acid / pharmacology
  • Quercetin / analogs & derivatives*
  • Quercetin / chemistry
  • Quercetin / pharmacology
  • Skin Aging / drug effects*
  • Tretinoin / chemistry
  • Tretinoin / pharmacology
  • Triterpenes / chemistry
  • Triterpenes / pharmacology*
  • Ultraviolet Rays
  • Ursolic Acid

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Interleukin-8
  • Triterpenes
  • betulonic acid
  • lupane
  • Tretinoin
  • Oleanolic Acid
  • betulin
  • Quercetin
  • taxifolin
  • MMP1 protein, human
  • Matrix Metalloproteinase 1
  • uvaol