Sleep to upscale, sleep to downscale: balancing homeostasis and plasticity

Neuron. 2012 Sep 20;75(6):933-5. doi: 10.1016/j.neuron.2012.09.007.

Abstract

The synaptic homeostasis hypothesis of sleep proposes that slow wave sleep (SWS) causes downscaling of synaptic networks potentiated during information uptake in prior wakefulness. Two studies in Neuron challenge this mechanism. Chauvette et al. (2012) show that SWS mediates an up- rather than downregulation of excitatory postsynaptic potential responses. Grosmark et al. (2012) find that downscaling in hippocampal networks might be mediated through REM sleep theta rather than SWS.

Publication types

  • Comment

MeSH terms

  • Animals
  • CA1 Region, Hippocampal / cytology*
  • Evoked Potentials / physiology*
  • Long-Term Potentiation / physiology*
  • Male
  • Neuronal Plasticity / physiology*
  • Neurons / physiology*
  • Sleep / physiology*
  • Sleep, REM / physiology*
  • Somatosensory Cortex / cytology*
  • Thalamus / physiology*
  • Theta Rhythm / physiology*