Abstract
Much of Parkinson's research over the last decade has focused on cellular stress as a candidate mechanism. In this issue of Neuron, a new study by Matta et al. (2012) addressing the biological functions of the Parkinson's gene LRRK2 now identifies a presynaptic substrate, homing in on the idea that synapse loss might be a central early aspect of neurodegeneration.
Copyright © 2012 Elsevier Inc. All rights reserved.
MeSH terms
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Acyltransferases / metabolism*
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Animals
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Drosophila Proteins / metabolism*
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Endocytosis / physiology*
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Humans
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Neuromuscular Junction / physiology*
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Protein Serine-Threonine Kinases / metabolism*
Substances
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Drosophila Proteins
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Acyltransferases
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endophilin A, Drosophila
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LRRK2 protein, human
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Protein Serine-Threonine Kinases