Neurodegeneration: new road leads back to the synapse

Neuron. 2012 Sep 20;75(6):935-8. doi: 10.1016/j.neuron.2012.09.006.

Abstract

Much of Parkinson's research over the last decade has focused on cellular stress as a candidate mechanism. In this issue of Neuron, a new study by Matta et al. (2012) addressing the biological functions of the Parkinson's gene LRRK2 now identifies a presynaptic substrate, homing in on the idea that synapse loss might be a central early aspect of neurodegeneration.

Publication types

  • Comment

MeSH terms

  • Acyltransferases / metabolism*
  • Animals
  • Drosophila Proteins / metabolism*
  • Endocytosis / physiology*
  • Humans
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Neuromuscular Junction / physiology*
  • Protein Serine-Threonine Kinases / metabolism*

Substances

  • Drosophila Proteins
  • Acyltransferases
  • endophilin A, Drosophila
  • LRRK2 protein, human
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Protein Serine-Threonine Kinases