iPSC technology to study human aging and aging-related disorders

Curr Opin Cell Biol. 2012 Dec;24(6):765-74. doi: 10.1016/j.ceb.2012.08.014. Epub 2012 Sep 18.


A global aging population, normally accompanied by a high incidence of aging-associated diseases, has prompted a renewed interest in basic research on human aging. Although encouraging progress has been achieved using animal models, the underlying fundamental mechanisms of aging remain largely unknown. Here, we review the human induced pluripotent stem cell (hiPSC)-based models of aging and aging-related diseases. These models seek to advance our knowledge of aging molecular mechanisms and help to develop strategies for treating aging-associated human diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging* / pathology
  • Animals
  • Biotechnology / methods*
  • Humans
  • Induced Pluripotent Stem Cells / cytology*
  • Models, Biological
  • Neurodegenerative Diseases / pathology
  • Progeria / pathology
  • Stem Cell Research*
  • Telomere / pathology