Abstract
A series of chalcones (3a-v) have been synthesized by condensation of β-ionone (1) with a variety of aldehydes (2a-v). The synthesized compounds have been screened for their in vitro antimicrobial activity against five bacterial and five fungal strains, using disc diffusion assay. The evaluated compounds display a wide range of activities, from completely inactive to the highly active compounds. Some of the compounds are also active against methicillin resistant staphylococcus aureus (MRSA).
Copyright © 2012 Elsevier Ltd. All rights reserved.
MeSH terms
-
Anti-Infective Agents / chemical synthesis
-
Anti-Infective Agents / chemistry*
-
Anti-Infective Agents / pharmacology*
-
Bacteria / drug effects
-
Bacterial Infections / drug therapy
-
Chalcones / chemical synthesis
-
Chalcones / chemistry*
-
Chalcones / pharmacology*
-
Fungi / drug effects
-
Humans
-
Methicillin-Resistant Staphylococcus aureus / drug effects
-
Microbial Sensitivity Tests
-
Mycoses / drug therapy
-
Norisoprenoids / chemical synthesis
-
Norisoprenoids / chemistry*
-
Norisoprenoids / pharmacology*
-
Staphylococcal Infections / drug therapy
Substances
-
Anti-Infective Agents
-
Chalcones
-
Norisoprenoids
-
beta-ionone