Expanding roles for SREBP in metabolism

Cell Metab. 2012 Oct 3;16(4):414-9. doi: 10.1016/j.cmet.2012.09.002. Epub 2012 Sep 20.

Abstract

Sterol regulatory element-binding protein (SREBP) transcription factors regulate cellular lipogenesis and lipid homeostasis. Recent studies reveal expanding roles for SREBPs with the description of new regulatory mechanisms, the identification of unexpected transcriptional targets, and the discovery of functions for SREBPs in type II diabetes, cancer, immunity, neuroprotection, and autophagy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2 / metabolism
  • Diabetes Mellitus, Type 2 / pathology
  • Humans
  • Immune System / metabolism
  • Insulin / metabolism
  • Lipids / biosynthesis
  • Mechanistic Target of Rapamycin Complex 1
  • Multiprotein Complexes / metabolism
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Signal Transduction
  • Sterol Regulatory Element Binding Proteins / metabolism*
  • TOR Serine-Threonine Kinases / metabolism

Substances

  • Insulin
  • Lipids
  • Multiprotein Complexes
  • Sterol Regulatory Element Binding Proteins
  • TOR Serine-Threonine Kinases
  • Mechanistic Target of Rapamycin Complex 1