Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

Nat Genet. 2012 Nov;44(11):1182-4. doi: 10.1038/ng.2417. Epub 2012 Sep 23.

Abstract

We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10(-15); OR = 1.50).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Breast Neoplasms, Male / genetics*
  • Chromosomes, Human, Pair 14
  • DNA-Binding Proteins / genetics*
  • European Continental Ancestry Group
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study*
  • Humans
  • Male
  • Polymorphism, Single Nucleotide
  • Risk Factors

Substances

  • DNA-Binding Proteins
  • RAD51B protein, human