Vasoactive intestinal peptide regulates mitosis, differentiation and survival of cultured sympathetic neuroblasts

Nature. 1990 Feb 8;343(6258):564-7. doi: 10.1038/343564a0.


Although acute, millisecond-to-millisecond actions of neurotransmitters are well documented, diverse longer-term effects have been discovered only recently. Emerging evidence indicates that these signals regulate a variety of neuronal processes, from phenotypic expression to neurite outgrowth. Here we show that a single putative transmitter, vasoactive intestinal peptide, can exert multiple, long-term effects simultaneously: it stimulates mitosis, promotes neurite outgrowth and enhances survival of sympathetic neuron precursors in culture. As the peptide seems to be a normal presynaptic transmitter in the sympathetic system, synaptic transmission may exert hitherto unexpected effects.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Axons / drug effects
  • Axons / physiology
  • Cell Differentiation / drug effects
  • Cell Survival / drug effects
  • Cells, Cultured
  • Ganglia, Sympathetic / cytology*
  • Ganglia, Sympathetic / embryology
  • Mitosis / drug effects*
  • Neurons / cytology*
  • Neurons / drug effects
  • Rats
  • Stem Cells / cytology*
  • Stem Cells / drug effects