Direct stereospecific amination of alkyl and aryl pinacol boronates

J Am Chem Soc. 2012 Oct 10;134(40):16449-51. doi: 10.1021/ja305448w. Epub 2012 Sep 24.


The direct amination of alkyl and aryl pinacol boronates is accomplished with lithiated methoxyamine. This reaction directly provides aliphatic and aromatic amines, stereospecifically, and without preactivation of the boronate substrate.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkanes / chemistry
  • Amination
  • Amines / chemistry
  • Boron Compounds / chemistry*
  • Hydrocarbons, Aromatic / chemistry*
  • Stereoisomerism


  • Alkanes
  • Amines
  • Boron Compounds
  • Hydrocarbons, Aromatic