The biliary elimination and enterohepatic circulation of ibuprofen in rats

Pharm Res. 1990 Jan;7(1):87-90. doi: 10.1023/a:1015847912059.


The biliary and urinary excretion of ibuprofen and its metabolites were determined in rats after intravenous and peroral administration of 25 and 100 mg/kg of the drug. Within 24 hours 48% of the low i.v. dose and 59% of the high i.v. dose were eliminated via bile as ibuprofen and its metabolites. Following oral administration 40 to 41% of the dose were recovered in bile, whereas 16 to 32% of the dose were eliminated in urine, resulting in an overall drug recovery of 66 to 79% within 24 hours. Upon infusion of bile containing ibuprofen and its metabolites into the duodenum substantial enterohepatic cycling of the drug occurred in the rat.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bile / metabolism*
  • Biotransformation
  • Chromatography, High Pressure Liquid
  • Enterohepatic Circulation*
  • Ibuprofen / pharmacokinetics*
  • Ibuprofen / urine
  • Male
  • Rats
  • Rats, Inbred Strains
  • Spectrophotometry, Ultraviolet


  • Ibuprofen