Robustness of signal transduction pathways

Cell Mol Life Sci. 2013 Jul;70(13):2259-69. doi: 10.1007/s00018-012-1162-7. Epub 2012 Sep 25.


Signal transduction pathways transduce information about the outside of the cell to the nucleus, regulating gene expression and cell fate. To reliably inform the cell about its surroundings, information transfer has to be robust against typical perturbation that a cell experiences. Robustness of several mammalian signaling pathways has been studied recently by quantitative experimentation and using mathematical modeling. Here, we review these studies, and describe the emerging concepts of robustness and the underlying mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bone Morphogenetic Proteins / metabolism*
  • Feedback, Physiological
  • MAP Kinase Signaling System / physiology
  • Models, Theoretical
  • Signal Transduction*


  • Bone Morphogenetic Proteins