The non-ossifying fibroma: a case report and review of the literature

Head Neck Pathol. 2013 Jun;7(2):203-10. doi: 10.1007/s12105-012-0399-7. Epub 2012 Sep 25.


The non-ossifying fibroma (NOF) is a benign, non-neoplastic lesion most commonly seen in the metaphyses of the long bones in children. While rare, the NOF has been reported in the mandible. The NOF in the extra-gnathic skeleton has a characteristic radiographic appearance, is typically asymptomatic and has a variable histologic make-up. Correlation of the radiographic appearance, clinical presentation and histopathology allows for differentiation of the NOF from odontogenic and non-odontogenic cysts and tumors. We report a new case of this interesting entity and review the radiographic, clinical and histologic features of the gnathic NOF reported in the literature. A thorough search of the English language literature returned a total of 19 cases of NOF involving the gnathic bones.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Diagnosis, Differential
  • Female
  • Fibroma / diagnostic imaging
  • Fibroma / pathology*
  • Fibroma / surgery
  • Granuloma, Giant Cell / diagnosis
  • Histiocytoma, Benign Fibrous / diagnosis
  • Histiocytoma, Malignant Fibrous / diagnosis
  • Humans
  • Hyperparathyroidism / diagnosis
  • Mandibular Diseases / diagnostic imaging
  • Mandibular Diseases / pathology*
  • Mandibular Diseases / surgery
  • Mandibular Neoplasms / diagnosis
  • Ossification, Heterotopic / pathology*
  • Radiography
  • Sarcoma / diagnosis
  • Treatment Outcome
  • Young Adult