Giant cell reparative granuloma of the skull base mimicking an intracranial tumor. Case report and review of the literature

Surg Neurol. 1990 Jan;33(1):52-6. doi: 10.1016/0090-3019(90)90226-f.


Giant cell reparative granuloma is an infrequent nontumoral lesion affecting particularly the maxillary and mandibular bones and only rarely the cranial bones. The etiopathogenesis is still controversial and differential diagnosis, especially from giant cell tumors of bone, is arduous. We report a case of giant cell reparative granuloma of the middle cranial fossa which behaved like an intracranial tumor and which we followed up for 15 years. We discuss the relevant literature and describe the essential features of this controversial lesion.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bone Diseases / diagnostic imaging*
  • Bone Diseases / pathology
  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / pathology
  • Diagnosis, Differential
  • Granuloma, Giant Cell / diagnostic imaging*
  • Granuloma, Giant Cell / pathology
  • Humans
  • Male
  • Radiography
  • Skull* / diagnostic imaging
  • Skull* / pathology