Approaches to Ras signaling modulation and treatment of Ras-dependent disorders: a patent review (2007--present)

Expert Opin Ther Pat. 2012 Nov;22(11):1263-87. doi: 10.1517/13543776.2012.728586. Epub 2012 Sep 26.


Introduction: Ras proteins are small GTPases molecular switches that cycle through two alternative conformational states, a GDP-bound inactive state and a GTP-bound active state. In the active state, Ras proteins interact with and modulate the activity of several downstream effectors regulating key cellular processes including proliferation, differentiation, survival, senescence, migration and metabolism. Activating mutations of RAS genes and of genes encoding Ras signaling members have a great incidence in proliferative disorders, such as cancer, immune and inflammatory diseases and developmental syndromes. Therefore, Ras and Ras signaling represent important clinical targets for the design and development of pharmaceutically active agents, including anticancer agents.

Areas covered: The authors summarize methods available to down-regulate the Ras pathway and review recent patents covering Ras signaling modulators, as well as methods designed to kill specifically cancer cells bearing activated RAS oncogene.

Expert opinion: Targeted therapy approach based on direct targeting of molecules specifically altered in Ras-dependent diseases is pursued with molecules that down-regulate expression or inhibit the biological function of mutant Ras or Ras signaling members. The low success rate in a clinical setting of molecules targeting activated members of the Ras pathway may require development of novel approaches, including combined and synthetic lethal therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / therapeutic use*
  • Drug Design
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / therapeutic use*
  • Genes, ras
  • Humans
  • Molecular Structure
  • Molecular Targeted Therapy*
  • Mutation
  • Neoplasms / drug therapy*
  • Neoplasms / enzymology
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Patents as Topic
  • Protein Conformation
  • Signal Transduction / drug effects*
  • Signal Transduction / genetics
  • Structure-Activity Relationship
  • ras Proteins / antagonists & inhibitors*
  • ras Proteins / chemistry
  • ras Proteins / genetics
  • ras Proteins / metabolism


  • Antineoplastic Agents
  • Enzyme Inhibitors
  • ras Proteins