Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Nov;10(11):1220-4.
doi: 10.1016/j.cgh.2012.09.020. Epub 2012 Sep 23.

Probiotics in Transition


Probiotics in Transition

Fergus Shanahan et al. Clin Gastroenterol Hepatol. .


Despite the hyperbole often linked with a popular research field, the scientific rationale for probiotics is sound. The probiotic concept is not new but is undergoing transition as knowledge of the gut microbiota in health and disease becomes translated to the clinic. Operationally, a probiotic represents a mimic of and/or supplement to the normal gut microbiota. Much confusion has arisen among consumers because of media misportrayals of probiotics as all being the same. However, with clarification of the molecular basis of host-microbe interactions, the selection criteria for probiotics and the delineation of their distinct mechanisms of action are improving. Most probiotics are from the genus Lactobacillus or Bifidobacterium; this is likely to change and diversify. Similarly, the development of new therapeutic strategies, such as the development of phagebiotics, psychobiotics, and genetically modified pharmabiotics, is poised to become a therapeutic reality.

Similar articles

See all similar articles

Cited by 4 articles

Publication types

LinkOut - more resources