Self-healing Microencapsulation of Biomacromolecules Without Organic Solvents

Angew Chem Int Ed Engl. 2012 Oct 22;51(43):10800-3. doi: 10.1002/anie.201206387. Epub 2012 Sep 26.

Abstract

Microencapsulation of biomacromolecules in PLGA is routinely performed with organic solvent through multiple complex steps deleterious to the biomacromolecule. The new self-healing based PLGA microencapsulation obviates micronization- and organic solvent-induced protein damage, provides very high encapsulation efficiency, exhibit stabilization and slow release of labile tetanus protein antigen, and provides long-term testosterone suppression in rats following a single injection of encapsulated leuprolide.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cattle
  • Coumarins / chemistry
  • Drug Compounding
  • Kinetics
  • Lactic Acid / chemistry
  • Macromolecular Substances / chemistry*
  • Muramidase / chemistry
  • Polyglycolic Acid / chemistry
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Serum Albumin, Bovine / chemistry
  • Solvents / chemistry*
  • Temperature
  • Trehalose / chemistry

Substances

  • Coumarins
  • Macromolecular Substances
  • Solvents
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Serum Albumin, Bovine
  • Lactic Acid
  • coumarin
  • Trehalose
  • Muramidase