[Adaptation to hypoxia and hyperoxia improves physical endurance: the role of reactive oxygen species and redox-signaling]

Ross Fiziol Zh Im I M Sechenova. 2012 Jun;98(6):793-807.
[Article in Russian]


We have conducted theoretical foundation, experimental analysis and a pilot study of a new method of adaptation to hypoxia and hyperoxia in the prevention of hypoxic and stress-induced disorders and improving the body's tolerance to physical stress. It has been shown in the experimental part that a combination of physical exercise with adaptation to hypoxia-hyperoxia significantly increased tolerance to acute physical load (APL) and its active phase. Analysis of lipid peroxidation processes, antioxidant enzymes and HSPs showed that short-term training for physical exercise by itself compensates the stressor, but not the hypoxic component of the APL, the combination of training with adaptation to hypoxia-hyperoxia completely normalizes the stressor and hypoxic components of APL. The pilot study has been performed to evaluate the effectiveness of hypoxic-hyperoxic training course in qualified young athletes with over-training syndrome. After completing the course of hypoxia-hyperoxia adaptation, 14 sessions, accompanied by light mode sports training, the athletes set the normalization of autonomic balance, increased resistance to acute hypoxia in hypoxic test, increased physical performance--increased PWC170, maximal oxygen consumption (VO2max) parameters, their relative values to body mass, diminished shift of rate pressure product in the load. Thus, we confirmed experimental findings that hypoxic-hyperoxic training optimizes hypoxic (increased athletes resistance to proper hypoxia) and stress (myocardium economy in acute physical stress testing) components in systemic adaptation and restoration of athletes' with over-training syndrome.

MeSH terms

  • Acclimatization / drug effects*
  • Acclimatization / physiology
  • Animals
  • Antioxidants / metabolism
  • Athletes
  • Exercise
  • Exercise Test
  • Gene Expression
  • Heat-Shock Proteins / genetics
  • Heat-Shock Proteins / metabolism
  • Humans
  • Hyperoxia / metabolism*
  • Hypoxia / metabolism*
  • Lipid Peroxidation / drug effects
  • Oxidation-Reduction
  • Oxygen / metabolism
  • Oxygen / pharmacology*
  • Oxygen Consumption / physiology
  • Physical Endurance / drug effects*
  • Physical Endurance / physiology
  • Rats
  • Rats, Wistar
  • Reactive Oxygen Species / metabolism
  • Signal Transduction / drug effects


  • Antioxidants
  • Heat-Shock Proteins
  • Reactive Oxygen Species
  • Oxygen