Microalbuminuria in adolescents with insulin-dependent diabetes mellitus

Am J Dis Child. 1990 Feb;144(2):234-7. doi: 10.1001/archpedi.1990.02150260114042.


Two hundred ten adolescents aged 12 to 18 years with insulin-dependent diabetes mellitus were screened for microalbuminuria (albumin excretion rate of 15 to 300 micrograms/min). Sixteen (7.6%) showed persistent microalbuminuria (mean albumin excretion rate of 70.9 +/- 56.2 micrograms/min). There were no significant differences between those with and without microalbuminuria with respect to age, sex, disease duration, and blood pressure over the previous 9 months and hemoglobin A1c level measured over the preceding 3 years. Within the group with microalbuminuria, there was no correlation between albumin excretion rate and blood pressure. However, there was a significant positive correlation between log albumin excretion rate and mean hemoglobin A1c values measured over the preceding 3 years. Our findings suggest that when microalbuminuria has developed, poorer metabolic control is associated with a higher albumin excretion rate. An actual rise in systemic blood pressure may not always precede the development of microalbuminuria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Albuminuria / complications*
  • Blood Pressure
  • Child
  • Diabetes Mellitus, Type 1 / complications*
  • Diabetes Mellitus, Type 1 / urine
  • Female
  • Hemoglobin A / analysis
  • Humans
  • Male


  • Hemoglobin A