Mapping rainbow trout immune genes involved in inflammation reveals conserved blocks of immune genes in teleosts

Anim Genet. 2013 Feb;44(1):107-13. doi: 10.1111/j.1365-2052.2011.02314.x. Epub 2012 Sep 26.

Abstract

We report the genetic map location of 14 genes involved in the inflammatory response to salmonid bacterial and viral pathogens, which brings the total number of immune genes mapped in rainbow trout (RT, Oncorhynchus mykiss) to 61. These genes were mapped as candidate genes that may be involved in resistance to bacterial kidney disease, as well as candidates for known QTL for resistance to infectious hematopoietic necrosis virus, infectious pancreatic necrosis virus and Ceratomyxa shasta. These QTL map to one or more of the linkage groups containing immune genes. The combined analysis of these linkage results and those of previously mapped immune genes in RT shows that many immune genes are found in syntenic blocks of genes that have been retained in teleosts despite species divergence and genome duplication events.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Chromosome Mapping / veterinary
  • Evolution, Molecular
  • Fish Diseases / genetics*
  • Fish Diseases / immunology*
  • Fish Diseases / microbiology
  • Fish Diseases / parasitology
  • Genetic Association Studies / veterinary
  • Genetic Linkage
  • Immunity, Innate*
  • Inflammation / genetics
  • Inflammation / veterinary*
  • Molecular Sequence Data
  • Oncorhynchus mykiss*
  • Phylogeny
  • Quantitative Trait Loci
  • Sequence Analysis, DNA / veterinary
  • Sequence Homology
  • Synteny